Literature summary extracted from

Mattern, J.; Eichhorn, U.; Kaina, B.; Volm, M.
O6-Methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts (1998), Int. J. Cancer, 77, 919-922.

Application

EC Number	Application	Comment	Organism
2.1.1.63	medicine	high level of enzyme in tumors and relative resistance to cyclophosphamide in lung cancer indicates that 6-O-methylguanine-DNA methyltransferase may be a predictive factor of resistance to cyclophosphamide	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.63	additional information	high level of enzyme in tumors and relative resistance to cyclophosphamide in lung cancer indicates that 6-O-methylguanine-DNA methyltransferase may be a predictive factor of resistance to cyclophosphamide	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.63	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.1.1.63	lung cancer cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.63	DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

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Release 2023.1 (January 2023)